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Because the human egg is capable of fertilization for only 12 to 24 hours after ovulation the date of ovulation may be taken as being the date of conception. However, ultrasound determination of the date of ovulation has the same imprecision as does the ultrasound estimate of the gestational age and, therefore, a precise date of conception cannot usually be determined as with in vitro fertilization. In addition, although a woman is most likely to become pregnant if she has sex on the day of ovulation conception may also occur from live sperm still in her reproductive tract on the day of ovulation if she had sex for up to five days before ovulation [26,27]. The due date may be estimated by adding days 9 months and 7 days to the first day of the last menstrual period LMP. This is the method used by "pregnancy wheels".

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Links with this icon indicate that you are leaving the CDC website. However, two other studies showed evidence supporting the use of the average fetal size to determine gestational age in twins and triplets very low quality evidence. No published health economics evidence was identified and no original health economic modelling was conducted for this review question.

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This review question focuses on what to measure when the scan is conducted in a women who is found to have a twin or triplet pregnancy; this has no additional resource implications and is, therefore, not relevant for further health economic analysis.

There is a need to determine which fetus should be used as the reference for the dating process in twin and triplet pregnancies. Accurate estimation of gestational age in such pregnancies is important because it forms the basis for predicting, assessing and managing the potential complications of the pregnancy. All outcomes specific in the review protocol were considered critical in terms of informing recommendations for clinical practice.

Pregnancy Lingo: What Does Gestation Mean?

With regard to which fetus to use, the ultrasound measurements of all fetuses will be taken in the pregnancy in any case. Evidence shows limited differences between smallest, largest and mean measurements to predict gestational age. The GDG therefore considered it more appropriate to date the pregnancy using the largest fetus.

The review question including its subsidiary questions was not identified as being of high priority for health economic evaluation.

Oct 26,   The actual date of conception generally isn't known for humans, so gestational age is the common way to measure how far along a pregnancy countryconnectionsqatar.com: Erica Hersh.

The available evidence was limited in quantity and quality. No randomised controlled trials RCTs were identified and most of the included studies were retrospective in design, using a variety of different methodologies for example, categorical versus continuous representation of gestational age, smaller and larger twins analysed independently or combined, size of fetus used to date pregnancy, head circumference versus crown-rump length.

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The quality of evidence for differences in fetal size in twin and triplet pregnancies versus singleton pregnancies was mainly very low. The quality of evidence for differences in dating of twin and triplet pregnancies versus singleton pregnancies was also mainly very low, as was the quality of evidence for prediction of growth discordance and accuracy of dating.

The majority of the studies did not report chorionicity or ethnicity. Only one study considered triplets, with the other studies concentrating on twins. This review question addressed whether there are differences in dating or the size of singleton versus twin or triplet pregnancies that should be taken into account when calculating gestational age in clinical practice.

In view of the limitations of the evidence, the GDG based its recommendation on consensus within the group and highlighted the need for further research in this area. The best interval for performing all three tests together is, therefore, when crown-rump length is between 45 mm and 84 mm at approximately 11 weeks 0 days to 13 weeks 6 days.

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In practice, it may not be possible to schedule all three tests at the same appointment, and in such circumstances more than one appointment in a short period may be needed. However, if the woman is known in advance to have a twin or triplet pregnancy for example, if such a pregnancy results from IVF treatment it may be possible to plan to schedule all three tests in a single appointment.

Evidence suggests that the mean twin measurement best reflects gestational age, both in the first and second trimesterwhether using crown-rump length in the first trimester or head circumference in the second trimester. The GDG recommends using the larger twin measurement to determine gestational age in the first half of pregnancy because using the mean twin measurement would lead to an underestimate of gestational age if the smaller twin were pathologically undergrown.

Similarly, the largest triplet measurement should be used to date triplet pregnancies.

Calculates pregnancy dates, forward from last period or backward from due date. Enter last menstrual period (LMP), current gestational age (GA), OR expected due date to determine the other two, plus estimated date of conception. Patients who are pregnant or may be pregnant. Please fill out required fields. Use to track and estimate pregnancy. Gestational age is the number of weeks that a baby has been in the uterus. The gestational age can be calculated using the current date and the patients estimated date of delivery. New charts for ultrasound dating of pregnancy. Ultrasound Obstet Gynecol. Sep;10(3) Choosing which fetus to use to date twin and triplet pregnancies. Three studies were identified for inclusion to address the question of which fetus should be used to establish gestational age in twin and triplet pregnancies. 33; 35; 37 The first study was a small prospective study, conducted in France, that compared gestational age predictions using crown-rump length measurements in twin.

This guideline specifies the care that women with twin and triplet pregnancies should receive that is additional or different from routine antenatal care for women with singleton pregnancies. Table 5. Note that for many women the twin or triplet pregnancy will be detected only after their routine booking appointment.

View in own window. However, the aim in this recommendation is to keep to a minimum the number of scan appointments that women need to attend within a short time, especially if it is already known that a woman has a twin or triplet pregnancy.

Pregnancy risks, clinical management and subsequent outcomes are very different for monochorionic and dichorionic twin pregnancies and monochorionic, dichorionic and trichorionic triplet pregnancies. Currently, there appears to be considerable variation and uncertainty in the practice of assigning chorionicity for twin and triplet pregnancies, leading to the GDG prioritising this question for review.

Diagnostic accuracy of various methods for determining chorionicity in twin and triplet pregnancies at different gestational ages was sought. What is the optimal method to determine chorionicity in multiple pregnancies? No existing NICE guidance was identified as being relevant to this review question. Fourteen studies investigating diagnostic accuracy of the following characteristics as determined by an ultrasound scan for determining chorionicity were identified for inclusion: Only two studies included triplets, and one of these included only one triplet pregnancy, meaning that sensitivity, specificity, positive predictive values PPVs and negative predictive values NPVs and likelihood ratio statistics could not be calculated using the triplet data in the study.

Six prospective cohort studies reported findings for using membrane thickness to determine chorionicity in twin pregnancies. Four prospective cohort studies reported on using the number of placental masses and a lambda or T-sign for determining chorionicity in twin pregnancies.

One prospective cohort study reported on using the number of membrane layers to determine chorionicity in twin pregnancies. One prospective cohort study conducted in the USA reported on using the number of placental sites to determine chorionicity in twin pregnancies. Seven studies reported findings for a mixture of methods for determining chorionicity in twin and triplet pregnancies.

Evidence profiles for this question are presented in Tables 4. GRADE summary of findings for scans performed at weeks of gestation. GRADE summary of findings for scans performed at more than 14 weeks of gestation.

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GRADE summary of findings for scans performed before 11 weeks of gestation or over a wide range of gestational ages with no mean age reported.

Table 4. Results for twin pregnancies are expressed in terms of detection of monochorionicity.

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For example, diagnostic accuracy values for the lambda sign are reported as absence of the sign which suggests monochorionicity rather than presence of the sign which suggests dichorionicity.

Results for triplet pregnancies are expressed in terms of detection of a monochorionic or dichorionic triplet pregnancy, rather than a trichorionic pregnancy.

Evidence was identified for a variety of methods used to determine chorionicity from ultrasound scans in twin and triplet pregnancies. The sensitivity and specificity of the methods used to determine chorionicity from ultrasound scans is generally high. The sensitivity for this test was also high.

For a mean or median gestational age of more than 14 weeks at the time of scan, results were reported for the use of membrane thickness very low quality evidencethe number of placental sites moderate quality evidence and two different composite methods very low and moderate quality evidence. The highest sensitivity was reported when membrane thickness was included in the composite method. Some studies reported findings for a gestational age of less than 11 weeks or over a wide range of gestational ages with no mean age reported.

The composite methods showed the strongest likelihood ratios and high sensitivity. The GDG is aware that the evidence presented may be biased due to analysis after the study concluded for patterns that were not specified before the study, particularly in studies that examined individual methods such as membrane thickness. In these studies, it is not clear how a clinician determining chorionicity on one measure alone such as subjectively thin or thick membrane would not be influenced by other cts of the ultrasound scan such as the number of gestational sacs.

No published health economic analyses were identified and this question was not prioritised for health economic analysis as part of the development of the guideline. The various measures based on ultrasound scans which were evaluated in terms of diagnostic accuracy could all be obtained from a single scan, and so the costs associated with undertaking individual and composite measures are likely to be similar. Sensitivity is the percentage of pregnancies found to be monochorionic at placental examination that were predicted to be monochorionic at scan true positive.

Specificity is the percentage of pregnancies found to be dichorionic at placental examination that were predicted to be dichorionic at scan true negative. PPV is the percentage of pregnancies predicted to be monochorionic by the scan that were confirmed at placental examination to be monochorionic.

NPV is the percentage of pregnancies predicted to be dichorionic by the scan that were confirmed at placental examination to be dichorionic.

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The GDG prioritised likelihood ratios and sensitivity when considering the evidence for different methods of predicting chorionicity. Determination of chorionicity is required to correctly stratify perinatal risk according to the type of twin or triplet pregnancy.

The gestational age would, therefore, be at least 3 to 4 weeks at the time of a reliable hCG pregnancy test. Twins When a twin pregnancy is the result of in vitro fertilization determination of gestational age should be made from the date of embryo transfer. Gestational diabetes is a type of diabetes that is first seen in a pregnant woman who did not have diabetes before she was pregnant. Some women have more than one pregnancy affected by gestational diabetes. Gestational diabetes usually shows up in the middle of pregnancy. Doctors most often test for it between 24 and 28 weeks of pregnancy. From first day of your period to the first day of your next period. Ranges from: 22 to Default = 28 Optional: Leave 28 if unsure. Estimated Fertility Window. Estimated Conception Date. #N#Estimated Gestational Age. #N#This is not a diagnosis. The calculations that are provided are estimates based on averages. How long is your cycle?

Since pregnancy risks, clinical management and subsequent outcomes are very different for monochorionic and dichorionic twin pregnancies and monochorionic, dichorionic and trichorionic triplet pregnanciesaccurately determining chorionicity is very important. Monochorionic twin pregnancies have a higher risk of developing complications, including feto-fetal transfusion syndrome FFTSfetal growth problems, structural abnormalities and overall perinatal loss compared with dichorionic twin pregnancies.

The assessment of chorionicity is easier in the first trimester than in later pregnancy and so it is important to assess and document chorionicity clearly at this gestational age. There is benefit in identifying true positives as women with monochorionic pregnancies will require additional fetal surveillance. Women can make decisions fully informed of risks and appropriate management of monochorionicity can be implemented.

Identification of true negatives women with dichorionic pregnancies will result in a saving of time and money by avoiding unnecessary additional interventions.

False positives will result in additional and unnecessary monitoring, anxiety and cost in women with dichorionic pregnancies. For instance, the EDD for a pregnancy that resulted from in vitro fertilization should be assigned using the age of the embryo and the date of transfer. As soon as data from the last menstrual period LMPthe first accurate ultrasound examination, or both are obtained, the gestational age and the EDD should be determined, discussed with the patient, and documented clearly in the medical record.

For the purposes of research and surveillance, the best obstetric estimate, rather than estimates based on the LMP alone, should be used as the measure for gestational age.

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An accurately assigned EDD early in prenatal care is among the most important results of evaluation and history taking. This information is vital for timing of appropriate obstetric care; scheduling and interpretation of certain antepartum tests; determining the appropriateness of fetal growth; and designing interventions to prevent preterm births, postterm births, and related morbidities.

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Appropriately performed obstetric ultrasonography has been shown to accurately determine fetal gestational age 1. A consistent and exacting approach to accurate dating is also a research and public health imperative because of the influence of dating on investigational protocols and vital statistics. This Committee Opinion outlines a standardized approach to estimate gestational age and the anticipated due date.

However, there is great usefulness in having a single, uniform standard within and between institutions that have access to high-quality ultrasonography as most, if not all, U.

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Accordingly, in creating recommendations and the associated summary table, single-point cutoffs were chosen based on expert review. Because this practice assumes a regular menstrual cycle of 28 days, with ovulation occurring on the 14th day after the beginning of the menstrual cycle, this practice does not account for inaccurate recall of the LMP, irregularities in cycle length, or variability in the timing of ovulation.

It has been reported that approximately one half of women accurately recall their LMP 2 3 4.

Ultrasound dating is based on a series of measurements of the gestational sac in very early pregnancies and of the embryo or fetus itself as pregnancy progresses. However, unless there is a great difference between what is seen on an ultrasound and what was reported Author: Dr. Anne Davis. ABSTRACT: Accurate dating of pregnancy is important to improve outcomes and is a research and public health imperative. As soon as data from the last menstrual period, the first accurate ultrasound examination, or both are obtained, the gestational age and the estimated due date (EDD) should be determined, discussed with the patient, and documented clearly in the medical record. Dating through pregnancy: a measure of growing up. Obstet Gynecol Surv ; Goldstein I, Reece EA, O'Connor TZ, Hobbins JC. Estimating gestational age in the term pregnancy with a model based on multiple indices of fetal maturity. Am J Obstet Gynecol ; Chambliss LR, Clark SL. Paper gestational age wheels are generally.

Accurate determination of gestational age can positively affect pregnancy outcomes. For instance, one study found a reduction in the need for postterm inductions in a group of women randomized to receive routine first-trimester ultrasonography compared with women who received only second-trimester ultrasonography 5.

A Cochrane review concluded that ultrasonography can reduce the need for postterm induction and lead to earlier detection of multiple gestations 6. Because decisions to change the EDD significantly affect pregnancy management, their implications should be discussed with patients and recorded in the medical record.

Measurements of the CRL are more accurate the earlier in the first trimester that ultrasonography is performed 11 15 16 17 The measurement used for dating should be the mean of three discrete CRL measurements when possible and should be obtained in a true midsagittal plane, with the genital tubercle and fetal spine longitudinally in view and the maximum length from cranium to caudal rump measured as a straight line 8 Mean sac diameter measurements are not recommended for estimating the due date.

Dating changes for smaller discrepancies are appropriate based on how early in the first trimester the ultrasound examination was performed and clinical assessment of the reliability of the LMP date Table 1. For example, for a day-5 embryo, the EDD would be days from the embryo replacement date.

Likewise, the EDD for a day-3 embryo would be days from the embryo replacement date.



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3 Comments

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